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Serious drug interactions can occur when certain medicines are used together with lopinavir and ritonavir. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
Some medicines can cause unwanted or dangerous effects when used with Kaletra. Your doctor may need to change your treatment plan if you use any of the following drugs:

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  • rifampin;

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  • midazolam, triazolam;

  • sildenafil (Revatio for pulmonary arterial hypertension);

  • St. John's wort; or

  • an ergot medicine (ergotamine, dihydroergotamine, methylergonovine).

To make sure Kaletra is safe for you, tell your doctor if you have:

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  • heart disease or a heart rhythm disorder;

  • a personal or family history of Long QT Syndrome;

  • pancreas problems;

  • diabetes;

  • low levels of potassium in your blood;

  • a bleeding disorder such as hemophilia;

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  • if you have ever used a protease inhibitor in the past.

It is not known whether Kaletra will harm an unborn baby. But HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Kaletra on the baby.
Kaletra can make birth control pills or patches less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Kaletra.
Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Kaletra is not approved for use by anyone younger than 14 days old. Premature infants should not receive the medication until it has been 14 days after their original due date.

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